Sassafras officinale (or S. albidum) is a plant native to eastern North America that is fast-growing, aromatic, and has three distinctive leaf shapes. It has been grown for medicinal purposes. All parts, including the stem, leaf, bark, wood, root, fruit, and flower, can be used for medicinal uses. The leaves have been used to treat wounds by some Native tribes. The bark was used for babies and children to treat a few conditions such as itching and fever, and it has also been used to treat other symptoms such as diarrhea, rheumatism, or scarlet fever.

Sassafras is a source of various phytochemicals, including alkaloids, terpenoids, saponins, steroids, and flavonoids. Sassafras was found to have anti-oxidant activity analyzed by DPPH, NBT/XO, and DCF/AAPH assays in a study that tested 35 plants. Additionally, the anti-oxidant activity of sassafras was found to be higher than traditionally used medicinal plants such as dandelion or sweet flag.